Health Education AIDS Liaison, Toronto


HEAL Toronto Annex

This is an index of miscellaneous articles not indexed on the main pages of the HEAL Toronto web site. These are articles I have come across in my investigations that may be of some interest. What you will find here: debates in the journals about various issues; mainstream articles that if you read between the lines offer evidence for dissident contentions; reports effecting public health policy; articles that have interesting info but suspect agendas (ie; dishing up AIDS dissidence to serve political agendas); things that just annoyed me. - Rob Johnston

KEY QUESTIONS ABOUT HIV
By Etienne de Harven, MD
Etienne de Harven, MD, is Professor Emeritus of Pathology, University of Toronto, and member of President T. Mbeki AIDS Advisory Panel
Translation of a lecture given by Prof. Etienne de Harven, in French, on September 14, 2001, in Grasse (France) during the 5th International Colloquium on "Drug addiction, Hepatitis and AIDS" (THS 5). AIDS being a major problem of public health, one must recognize, however, the existence of a considerable controversy regarding the causes of this syndrome.

Treatment of AIDS and HIV-Related Conditions: 2001
Ronald H. Goldschmidt, et al. J Am Board Fam Pract 14(4):283-309, (2001)
Table 1, "Treatment Regimens for HIV Disease", is a labyrinth of drug combinations, toxic effects, and counter measures to toxicity.

Prevention of HIV transmission from mother to infant


Interventions aimed at decreasing the risk of mother-to-child transmission of HIV infection (Cochrane Review).
The Cochrane Library, Issue 1, 2000. Oxford: Update Software.
The drift of this review is certainly tendentious; excluding studies that showed favorable results from vitamin therapy, for instance. The references are useful.

Oxidative DNA damage in fetal tissues after transplacental exposure to 3'-azido-3'-deoxythymidine (AZT).
Carcinogenesis 2000 May;21(5):1059-1062

Genotoxicity of 3'-azido-3'-deoxythymidine in the human lymphoblastoid cell line, TK6: relationships between DNA incorporation, mutant frequency, and spectrum of deletion mutations in HPRT. Mutat Res 1999 Oct 19;429(2):249-59

Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues.
Lancet. 1999 Sep 25;354(9184):1084-9.

more abstracts and citations tracing the history of this "intervention:

Zidovudine for the prevention of HIV transmission from mother to infant.
MMWR Morb Mortal Wkly Rep. 1994 Apr 29;43(16):285-7.
Try this title as a search query at PubMed/Medline.

Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group.
N Engl J Med. 1994 Nov 3;331(18):1173-80.

A risk-benefit assessment of zidovudine in the prevention of perinatal HIV transmission.
Drug Saf. 1995 Apr;12(4):274-82. Review

U.S. Public Health Service recommendations for human immunodeficiency virus counseling and voluntary testing for pregnant women.
MMWR Morb Mortal Wkly Rep. 1995 Jul 7;44(RR-7):1-15.

Prevention of perinatal transmission of human immunodeficiency virus: a progress report 2 years after completion of AIDS Clinical Trials Group trial 076.
Clin Infect Dis. 1996 Sep;23(3):438-41. Review.

[The reduction of mother-child transmission of HIV infection in developing countries: potential intervention strategies, obstacles to implementation and perspectives. The Reduction of Mother-Child Transmission of HIV Infection in Africa Group].
Sante. 1997 Mar-Apr;7(2):115-25. French.

Zidovudine to prevent mother-to-infant HIV transmission in developing countries: any questions?
Van der Stuyft P, Boelaert M, Temmerman M.
Trop Med Int Health. 1998 Sep;3(9):689-90. No abstract available.

Preventing transmission of HIV from mother to child--is South Africa ready and willing?
Wilkinson D, McIntyre J.
S Afr Med J. 1998 Oct;88(10):1304-6. No abstract available.

The mother-to-child HIV transmission debate.
[various authors]
S Afr Med J. 1999 Feb;89(2) No abstract available.

The mode of delivery and the risk of vertical transmission of human immunodeficiency virus type 1--a meta-analysis of 15 prospective cohort studies. The International Perinatal HIV Group.
N Engl J Med. 1999 Apr 1;340(13):977-87.

The effects of zidovudine in the subset of infants infected with human immunodeficiency virus type-1 (Pediatric AIDS Clinical Trials Group Protocol 076).
J Pediatr. 1999 Jun;134(6):717-24.

Zidovudine to prevent mother-to-infant HIV transmission in developing countries: a view from Thailand.
Kumphitak A, Cawthorne P, Lakhonphol S, Kasi-Sedapan S, Sanaeha S, Unchit N, Wilson D.
Trop Med Int Health. 1999 Mar;4(3):236-7; discussion 237-8. No abstract available.

For the latest citations search "Zidovudine for the prevention of HIV transmission" at PubMed/Medline. (If you search "AZT" over 6000 citations come up!)

***


Survival after introduction of HAART in people with known duration of HIV-1 infection
The CASCADE Collaboration
The Lancet; London; Apr 1, 2000

CMAJ on Routine Prenatal HIV Screening

Evidence-based guidelines for universal counselling and offering of HIV testing in pregnancy in Canada
Lindy Samson, MD; Susan King, MD
CMAJ 1998;158:1449-57

Access to prenatal HIV testing
Robert S. Remis, MD, MPH; David M. Patrick, MD, MHSc
CMAJ 1998;158:1469-70


With HIV prevalence among women increasing, more provinces encourage prenatal testing

Ann Silversides
CMAJ 1998;158:1518-9

False-positive results in antenatal HIV screening
Laura A. Magee; Kellie E. Murphy; Peter von Dadelszen
CMAJ 1999;160;1285
Response from: L. Samson, S. King

Compulsory HIV tests
R. Walter Dunn, MB
CMAJ 1999;160:1286
Response from: D.M. Patrick, D. Burdge

***


False-positive HIV Test: Implications for the Patient. [Letters]
JAMA, Volume 269(22).Jun 9, 1993.2847

Relation Of The Course Of HIV Infection In Children To The Severity Of The Disease In Their Mothers At Delivery. [Original Article]
Blanche: N Engl J Med, Volume 330(5).Feb 3, 1994.pp 308-312

AIDS CASES TO DOUBLE (With the Deft Stroke of a Bureaucrat's Pen)
by Gene Franks -- Gazette #36, May 1991.

Scaring Us Toward Global Government
By Robert W. Lee -- THE NEW AMERICAN - Copyright 1997

Surrogate Markers in AIDS Research: Is There Truth in Numbers? [Controversies]
Levy: JAMA, Volume 276(2).July 10, 1996.161-162

Controversies: Does the CD4+ Cell Count Reflect Clinical Efficacy? [Letters: In Reply]
Levy: JAMA, Volume 276(15).October 16, 1996.1219

Surrogate End Points in Clinical Trials: Are We Being Misled?
Fleming: Ann Intern Med, Volume 125(7).October 1, 1996.pp 605-613.

Preliminary analysis of the Concorde trial. [Letters to the Editor]
Aboulker: Lancet, Volume 341(8849).Apr 3, 1993.pp 889-890.

Misdiagnosis of HIV Infection by HIV-1 Plasma Viral Load Testing: A Case Series [Brief Communications]
Rich: Ann Intern Med, Volume 130(1).January 5, 1999.37-39

HIV Testing in Pregnant Women [Letters]
Wong: Ann Intern Med, Volume 129(12).December 15, 1998.1075

1. Nakchbandi IA, Longenecker JC, Ricksecker MA, Latta RA, Healton C, Smith DG. A decision analysis of mandatory compared with voluntary HIV testing in pregnant women. Ann Intern Med. 1998;128:760-7.

Nakchbandi replies

Antiretroviral Therapy For Adult HIV-Infected Patients: Recommendations From a State-of-the-Art Conference [Special Communication]
Sande: JAMA, Volume 270(21).Dec 1, 1993.pp 2583-2589.

The 1987 Revision of the CDC Surveillance Case Definition for Acquired Immunodeficiency Syndrome
HEAL Commentary

Differential Survival of Patients With AIDS According to the 1987 and 1993 CDC Case Definitions[Brief Report]
Vella: JAMA, Volume 271(15).April 20, 1994.1197-1199

Influence of infant-feeding patterns on early mother-to-child transmission of HIV-1 in Durban, South Africa: a prospective cohort study [Early Reports]
Coutsoudis: Lancet, Volume 354(9177).August 7, 1999.471-476

Infant feeding and HIV-1 transmission [Commentary]
Newell: Lancet, Volume 354(9177).August 7, 1999.442-443


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